As far as consistency and look of the mixed formula in each bottle, they were both incredibly similar in their qualities. Both brands have added DHA (an omega-3 fatty acid in their product.  Enfamil was the first to add Prebiotics nutrients in baby formulas which help the growth of friendly gut bacteria. A lot of infants I have seen on Enfamil are either overweight or had to switch to another kind because of the gassiness or constant spit up. As long as your baby does not appear to be struggling or constipated, do not worry about how frequent they are “going” but just that the baby is comfortable. Many a mother does not get time to nurse their babies as work commitments keep them away from home. I screwed the ring/nipple onto our Dr. Brown's bottle and used the Similac powder, and she takes it fine. In such cases, infant formula is the best replacement for mothers’ milk. Both brands have added DHA (an omega-3 fatty acid in their product.  Enfamil was the first to add Prebiotics nutrients in baby formulas which help the growth of friendly gut bacteria. Lutein plays a major role in developing a healthy vision, and DHA is required for the development of the brain. If you have decided to purchase the powder formula, then you have to make sure that you don’t add less or more than the recommended quantity per serve. Its supposed positive effects on brain development and its lack of added sugars helped it win this match against Similac Pro-Advance. I have two questions. Similac Expert Care for Diarrhea (for those frequently suffer from diarrhea); Similac Expert Care Alimentum (for babies experiencing protein sensitivity or food allergies); Similac Sensitive for Spit-Up (those suffering from frequent spit-ups); Similac Expert Care NeoSure (for prematurely born babies); Similac Sensitive ( for babies with lactose sensitivity issues); Similac Soy Isomil and Similac Go & Grow Soy (soy-based formula for infants and toddlers), The actual Enfamil Vs. Similac advantages and disadvantages come to the fore only when we talk about the customized. There are also alternatives to cow’s milk formula, like soy, if you believe your child may be lactose intolerant. Similac Advance has a higher amount of vitamin D, riboflavin, thiamin, niacin, and biotin than its rival. A huge positive in each brand’s ingredients is that neither use any GMO’s. In fact, it is easier to introduce room temperature or even cold water mixed with formula, so baby does not become too accustomed to it being warm. Most popular products from Similac are ‘Similac Advance” for infants up to 12 months and ‘Similac Go & Grow’ for toddlers. If the baby has the powder formula in excess, it might upset the baby’s stomach. Offering expert nutrition at every stage, they're designed to be used with Enfamil Nursette bottles, as well as other standard or classic-size bottle openings, offering you a wide variety of options for pairing. Enfamil is the #1 infant formula brand recommended by pediatricians and is used in more than 8 out of 10 birthing hospitals. A mom might be struggling to produce enough breast milk and need to supplement, another family perhaps simply did not want to breastfeed or were unable to. We tried numerous nipples and could not find any that worked. But if you really want rings and nipples to fit those similac bottles just go buy the parent's choice or gerber bottles. Similac Infant Nipples & Rings, Standard Flow, Ready to Use, Pack of 10 (0 - 12 Months) Enfamil Neuropro Gentlease Ready To Feed Infant Formula 2 fl. If the powder is not diluted well, it might also clog the bottle’s nipple. Both brands have particular categories of products for infants in rare health conditions or nutritional deficiencies. None of the amounts differ so greatly from the competitor that it makes an impact, except for one key ingredient: sugar. Similac Sensitive lists milk protein isolate as a source of protein. These brands strictly adhere to the guidelines of the FDA and are approved by Government health agencies. After making an in-depth comparative analysis of both of these products, I have found only a few minor differences between both the brands. 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