Follow up and relapse analysis of an inositol study of depression. 1989;341(6239):197-205. Phosphatidyl choline is an essential chemical when it comes to brain cell reproduction, and can help improve focus, as … I'm 75, energetic and still work! Q: Dr. Sherry Rogers prescribed Phosphatidylcholine for both my husband and me in the early 1990s. Psychophamacology. Citicoline, also known as CDP Choline, Cytidine diphosphate-choline, is a popular nootropic known to improve cognitive function and brain health. Phosphatidycholine vs Phosphatidylserine. Acta Psychiatr Scand. Since depression affects the quality of life and productivity of the patient, an early diagnosis is crucial for effective treatment. Source: Phosphatidylcholine products that come from plants, all have two or more than two different types of phospholipids where there is a competing interest between the phospholipids (Phosphatidylcholine, Phosphotidylinositol and phosphotidyletanolamine). Ten females were recruited for this study, 8 with MDD and 2 with bipolar depression. ConsumerLab's answer explains the evidence for supplements promoted to help with brain function and cognition. After administering 12g of inositol or placebo for four weeks, the authors found a significant reduction in depression scores in the inositol group compared to the placebo group. Recommended treatment differs based on disease severity. We stopped taking it for a while, due at least in part, to financial reasons. Nature. Phosphatidylserine works for me, BUT only one brand, and one form.. SOFTGEL. After four weeks, authors found that there was no significant difference between the groups on HDRS scores, however there was an expected improvement in the scores of both groups as both groups received SSRI therapy. Interest in administering phospholipids for treatment of MDD stems from animal and human data demonstrating that certain areas of the brain, plasma and CSF can show deficiencies in phospholipids in depressed patients. JAMA. In conclusion, the three RCTs (Levine 1995, Levine 1999, Nemets 1999) show conflicting results regarding the treatment effect of inositol. Patten SB, Wang JL, Williams JV, Currie S. Descriptive epidemiology of major depression in Canada . Barkai AL, Dunner DL, Gross HA, Mayo P, Fieve RR. The difference between PC and phosphatidylserine (PS) is a mere swapping of the non-fatty choline for serine. The remainder of the article will focus on inositol and phosphatidylserine as possible treatments for major depression. The type of patients (MDD, unipolar depression versus bipolar disorder) and the use of adjunct pharmacotherapy may explain the difference in results. Israel Journal of Psychiatry and Related Sciences. 2004;28(4):731-738. This feature is restricted to active members. Kidd PM. Castilho JC, Perry JC, Andreatini R, Vital MA. Can homeopathy aid in Alzheimer’s Disease. 2010 Jan 6;303(1):47-53. Also, it is thought to increase the density of dopamine receptors in the brain. 1998;29:580 – 586. 2000;144:158 – 162. ConsumerLab explores the efficacy of Prevagen. Promises of improved memory and impeccable cognitive processing are great but we must warn you that supplements even foods … Patients received a dose of 600mg of phosphatidylserine per day. Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Soleimani L, Lapidus K, Iosifescu D. Diagnosis and treatment of major depressive disorder. This review will focus on the effects of administering phosphatidylinositol, phosphatidylserine or phosphatidylcholine on unipolar depression by reviewing current human trials and animal data. Middleton H, Shaw I, Feder G. NICE guidelines for the management of depression. Exercise rehabilitation for cancer patients, Health Canada announces funding for clinical trials of liberation therapy for MS patients, Pete Evans slammed for ‘unacceptable’ comments about Dr. Harry Nespolon, Throne Speech: Premiers Should Not Play Partisan Politics with Health Care; Concrete Commitments Needed From Provincial & Federal Governments, Health Canada Authorizes COVID-19 Phase 2 Clinical Trial for Patented Plant-based Curcumin Extract,, Supreme Court of Canada dismisses Sobeys’ appeal. : CD004049. Levine, J, et al. © IHR Magazine and | All rights reserved. Patients with severe depression should be closely monitored for suicidality with referral or admission to hospital if necessary (Soleimani 2011). Learn more about Prevagen, including clinical studies on Prevagen's impact on memory & cognition, safety, pricing, and an FDA warning letter. However, it does provide choline, which is a component of the neurotransmitter acetylcholine. Both of these phospholipids, or phosphate based acids, perform essential functions in the body, and more specifically the cell membranes. It has been reported that 60-70% of patients with depression will respond to treatment if diagnosed early and appropriately treated (Shah 1999).

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